Vilazodone: what it is and how it works

Vilazodone (brand name Viibryd) is an oral antidepressant used mainly for major depressive disorder. It acts like an SSRI and also partly stimulates 5-HT1A receptors. That combination can change serotonin signaling differently from older drugs. People try vilazodone when a standard SSRI hasn’t worked or when a prescriber thinks its profile might fit better.

How to take vilazodone

Your doctor usually starts vilazodone at 10 mg once daily for a week, then increases to 20 mg. The typical effective dose is 20–40 mg once daily. Take it with food — a full meal improves absorption and helps the medicine reach intended levels in your bloodstream. If you miss a dose, take it as soon as you remember the same day; don’t double up the next day.

Tell your prescriber about every medicine and supplement you take. Vilazodone can interact with monoamine oxidase inhibitors (MAOIs) and other serotonergic drugs, raising the risk of serotonin syndrome. Also check with your doctor before using strong CYP3A4 inhibitors or inducers — these can change vilazodone levels.

Common side effects and safety tips

Expect some side effects early on: nausea, diarrhea, headache, dizziness, and trouble sleeping are common. Taking the pill with food and moving slowly when standing can reduce dizziness and nausea. Sexual side effects happen with many antidepressants; some people report fewer sexual problems with vilazodone, but research is mixed, so watch for changes and tell your provider.

Do not stop vilazodone suddenly. Stopping abruptly can cause withdrawal-like symptoms such as irritability, sleep changes, or flu-like feelings. Your doctor will suggest a gradual taper. If mood worsens or you get new suicidal thoughts, call your provider or emergency services right away — this is especially important for young adults and teens early in treatment.

Pregnancy and breastfeeding: evidence is limited. If you’re pregnant or planning to become pregnant, discuss risks and alternatives with your doctor. For older adults or people with liver problems, dose adjustments may be needed.

How long before it helps? Some people notice better mood or sleep in 2–4 weeks, but full benefit can take 6–8 weeks. Keep regular follow-ups so your prescriber can track response, side effects, and any drug interactions.

Quick comparisons: vilazodone is similar to SSRIs for depression but differs by partial 5-HT1A activity. That may change side effects or response for some people, but it’s not a guaranteed advantage. Choice of antidepressant depends on your history, side-effect tolerance, other meds, and what your clinician recommends.

If you want more details — dosing charts, patient tips, or how vilazodone compares to other options — talk to your clinician or pharmacist. They can tailor advice to your health, other medicines, and treatment goals.