Fluconazole: What It Treats and How to Use It Safely

Fluconazole is a commonly prescribed antifungal taken by mouth or given by IV. It treats infections caused by Candida species, including vaginal yeast infections, oral thrush, esophageal candidiasis, and some systemic fungal infections. People like it because a single tablet can clear a simple vaginal yeast infection, while more serious infections need longer courses or IV therapy.

How to take fluconazole

Oral dosing varies by infection. A single 150 mg pill is the usual quick option for uncomplicated vaginal yeast. Oral thrush or esophageal infections usually require daily doses for several days to weeks, and severe systemic infections need higher doses under hospital care. Always follow your prescriber’s instructions. Don’t double up doses or stop early just because you feel better. If you miss a dose, take it as soon as you remember unless it’s almost time for the next one—then skip the missed dose.

Side effects and safety tips

Most people tolerate fluconazole well. Common side effects include nausea, headache, stomach pain, and rash. Serious but rare problems include liver injury and severe allergic reactions. If you notice yellowing skin or eyes, very dark urine, persistent nausea, or an unexplained rash, stop the drug and contact your doctor right away.

Drug interactions matter. Fluconazole can raise levels of warfarin, some statins, certain diabetes medications, carbamazepine, and others. It also affects liver enzymes that process many drugs. Tell your provider about every medication and supplement you take, including over-the-counter and herbal products.

Talk to your clinician before using fluconazole during pregnancy. Single low-dose oral fluconazole for vaginal yeast is generally avoided in pregnancy in many places; topical treatments are usually recommended instead. Breastfeeding people should check with a provider—small amounts pass into breast milk but most short courses are considered low risk.

When to see a doctor: If symptoms don’t improve within the expected timeframe, come back for a check. Recurrent or severe fungal infections need testing and sometimes a different antifungal. Also seek care for signs of liver trouble or a severe allergic reaction. If you have a weakened immune system, diabetes, or recent antibiotic use, mention that—these factors change treatment choices.

Quick practical tips: Use topical azoles like clotrimazole if a local treatment is appropriate and you prefer it. Avoid alcohol while you’re unwell and check interactions with medications like warfarin. Store tablets in a cool, dry place and keep them out of reach of children.

Resistance and recurrent infections can happen, especially in people who use multiple courses or live with weakened immunity. If you have more than four yeast infections a year, ask for testing. Your clinician may order a culture to identify the fungus and choose a different drug or longer suppressive therapy. Never share prescription antifungals and avoid buying medication from unknown online sellers without checking credentials. Ask questions often.

If you want more on antifungals, antibiotics, or safe online pharmacy options, we have detailed guides and reviews to help you make informed choices.